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956613-01-7

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956613-01-7 Structure

956613-01-7 Structure
IdentificationBack Directory
[Name]

Pyridine, 4-[5-(6-methoxy-2-naphthalenyl)-1-methyl-2-[2-methyl-4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]-
[CAS]

956613-01-7
[Synonyms]

SB-633825
Pyridine, 4-[5-(6-methoxy-2-naphthalenyl)-1-methyl-2-[2-methyl-4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]-
[Molecular Formula]

C28H25N3O3S
[MDL Number]

MFCD32708496
[MOL File]

956613-01-7.mol
[Molecular Weight]

483.58
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis[1].
[IC 50]

Tie2: 3.5 nM (IC50)
[References]

[1] Elkins JM, et al. Comprehensive characterization of the Published Kinase Inhibitor Set. Nat Biotechnol. 2016 Jan;34(1):95-103. DOI:10.1038/nbt.3374
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