| Identification | Back Directory | [Name]
8-Bromo-6-chloroimidazo[1,2-a]pyridine | [CAS]
957187-27-8 | [Synonyms]
8-Bromo-6-chloroimidazo[1,2-a]pyridine
6-chloro-8-bromoimidazo[1,2-a]pyridine
IMidazo[1,2-a]pyridine, 8-broMo-6-chloro- | [Molecular Formula]
C7H4BrClN2 | [MDL Number]
MFCD12828062 | [MOL File]
957187-27-8.mol | [Molecular Weight]
231.48 |
| Chemical Properties | Back Directory | [Melting point ]
125-128℃ | [density ]
1.84±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
2.23±0.50(Predicted) | [Appearance]
White to off-white Solid | [Water Solubility ]
Slightly soluble in water. |
| Hazard Information | Back Directory | [Uses]
8-Bromo-6-chloroimidazo[1,2-a]pyridine is used as an organic chemical synthesis intermediate. | [Synthesis]
3-Bromo-5-chloropyridin-2-amine (10 g, 49 mmol) and chloroacetaldehyde (50% aqueous, 12 mL, 98 mmol) were mixed in ethanol (100 mL) and the reaction was heated at 50 °C overnight. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated. To the concentrated residue was added acetone (30 mL) and stirred rapidly for 2 hours. The resulting solid was collected by filtration and dried to afford the target product 8-bromo-6-chloroimidazo[1,2-a]pyridine (10.0 g, 89% yield). Mass spectrometry analysis showed [M + H]+ peak of 231. 1H NMR (500 MHz, DMSO) data were as follows: δ 9.20 (s, 1H), 8.33 (s, 1H), 8.29 (s, 1H), 8.09 (s, 1H). | [References]
[1] Patent: US2013/116262, 2013, A1. Location in patent: Paragraph 0195; 0196; 0197
[2] Patent: WO2011/72064, 2011, A1. Location in patent: Page/Page column 74 |
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| Company Name: |
Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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