| Identification | Back Directory | [Name]
7-iodo-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one | [CAS]
957193-64-5 | [Synonyms]
7-Iodo-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)
7-iodo-1H,2H,3H,4H-pyrido[2,3-b]pyrazin-2-one
7-iodo-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one
3,4-dihydro-7-iodopyrido[2,3-b]pyrazin-2(1H)-one
7-iodo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one
Pyrido[2,3-b]pyrazin-2(1H)-one, 3,4-dihydro-7-iodo- | [Molecular Formula]
C7H6IN3O | [MDL Number]
MFCD12547673 | [MOL File]
957193-64-5.mol | [Molecular Weight]
275.05 |
| Hazard Information | Back Directory | [Synthesis]
Example 2. Synthesis of 7-iodo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-2-one: Ethyl (5-iodo-3-nitropyridin-2-yl)glycinate (17 g) was dissolved in ethanol. SnCl2-2H2O was added to the solution and the reaction mixture was heated to 80 °C and kept for two hours. After completion of the reaction, the resulting precipitate was collected by filtration and washed with ethanol to afford 7-iodo-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-one as a rust-colored solid in 59-77% yield. The melting point was 81 °C. LCMS analysis showed m/z = 275.91 ([M+H]+).1H-NMR (DMSO-d6, 400 MHz) δ 3.94 (s, 2H), 6.94 (bs, 1H), 7.12 (d, J = 1.8 Hz, 1H), 7.74 (d, J = 1.8 Hz, 1H), 10.40 (bs, 1H) . | [References]
[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 12, p. 4351 - 4362
[2] Patent: WO2007/130468, 2007, A2. Location in patent: Page/Page column 84-85 |
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