| Identification | Back Directory | [Name]
Furin Inhibitor II TFA | [CAS]
958204-56-3 | [Synonyms]
Hexa-D-arginine TFA
Furin Inhibitor II TFA | [Molecular Formula]
C38H76F3N25O8 | [MDL Number]
MFCD18633383 | [MOL File]
958204-56-3.mol | [Molecular Weight]
1068.19 |
| Hazard Information | Back Directory | [Uses]
Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3]. | [in vivo]
Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α[1]. | [References]
[1] Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9. DOI:10.1128/IAI.70.12.7136-7139.2002
[2] Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5. DOI:10.1128/IAI.72.1.602-605.2004
[3] Cameron A, et al. Polyarginines are potent furin inhibitors. J Biol Chem. 2000 Nov 24;275(47):36741-9. DOI:10.1074/jbc.M003848200 |
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MedChemExpress
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