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958888-32-9

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958888-32-9 Structure

958888-32-9 Structure
IdentificationBack Directory
[Name]

WK88-1
[CAS]

958888-32-9
[Synonyms]

WK88-1
Reaxys ID: 18332181
Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-4,5-dihydro-
[Molecular Formula]

C28H42N2O6
[MOL File]

958888-32-9.mol
[Molecular Weight]

502.64
Chemical PropertiesBack Directory
[Boiling point ]

692.1±55.0 °C(Predicted)
[density ]

1.14±0.1 g/cm3(Predicted)
[pka]

13.20±0.50(Predicted)
Hazard InformationBack Directory
[Uses]

WK88-1, a Hsp90 inhibitor, induces overall degradation of multiple oncogenic signaling molecules including EGFR, ErbB2 and ErbB3, leading to subsequent growth arrest and apoptosis in the Gefitinib-resistant H1975 cell line[1].
[References]

[1] Young-Soo Hong, et al. Hsp90 inhibition by WK88-1 potently suppresses the growth of gefitinib-resistant H1975 cells harboring the T790M mutation in EGFR. Oncol Rep. 2014 Jun;31(6):2619-24. DOI:10.3892/or.2014.3161
958888-32-9 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Company Name: BOC Sciences  
Tel: 16314854226
Website: www.bocsci.com
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