| Identification | Back Directory | [Name]
5-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-5-oxopentanoic acid | [CAS]
959053-53-3 | [Synonyms]
N-Boc-piperazine-C3-COOH
1-Piperazinepentanoic acid, 4-[(1,1-dimethylethoxy)carbonyl]-δ-oxo-
5-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]-5-oxopentanoic acid | [Molecular Formula]
C14H24N2O5 | [MDL Number]
MFCD10042180 | [MOL File]
959053-53-3.mol | [Molecular Weight]
300.35 |
| Hazard Information | Back Directory | [Uses]
N-Boc-piperazine-C3-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-N-piperazine-C3-COOH can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183)[1]. | [Biological Activity]
N-Boc-piperazine-C3-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-N-piperazine-C3-COOH can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 [1]. | [IC 50]
Alkyl/ether | [References]
[1]. Cheng B, Ren Y, Cao H, Chen J. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377. |
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