| Identification | Back Directory | [Name]
TRIMIDOX | [CAS]
95933-74-7 | [Synonyms]
VF 233
TRIMIDOX
Trimidox Exclusive
MSLJYSGFUMYUDX-UHFFFAOYSA-N
Benzenecarboximidamide, N,3,4,5-tetrahydroxy-
4-[amino-(hydroxyamino)methylidene]-2,6-dihydroxycyclohexa-2,5-dien-1-one | [Molecular Formula]
C7H8N2O4 | [MDL Number]
MFCD02661510 | [MOL File]
95933-74-7.mol | [Molecular Weight]
184.15 |
| Hazard Information | Back Directory | [Description]
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 μM. | [Uses]
Trimidox is a specific ribonucleotide reductase inhibitor. | [Definition]
ChEBI: Trimidox is a benzenetriol. | [storage]
Store at -20°C | [References]
[1] szekeres t, fritzer m, strobl h, et al. synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia hl-60 cells[j]. blood, 1994, 84(12): 4316-4321.
[2] elledge s j, zhou z, allen j b. ribonucleotide reductase: regulation, regulation, regulation[j]. trends in biochemical sciences, 1992, 17(3): 119-123. |
|
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|