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7-Hydroxyneolamellarin A is a natural product that could be derived from sponge Dendrilla nigra. 7-Hydroxyneolamellarin A is a potent hypoxia-inducible factor-1α (HIF-1α) inhibitor. 7-Hydroxyneolamellarin A attenuates the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibits vascular epidermal growth factor (VEGF) transcriptional activity. 7-Hydroxyneolamellarin A can be used in research of cancer[1]. | [in vivo]
7-Hydroxyneolamellarin A (15 mg/kg; i.v.; BALB/c mice with 4T1 cells xenografts) inhibits tumor growth in vivo[1]. | Animal Model: | BALB/c mice with 4T1 cells xenografts[1] | | Dosage: | 15 mg/kg | | Administration: | Intravenous injection; every 2 days for 16 days | | Result: | Inhibited tumor growth in vivo. |
| [References]
[1] Li G, et, al. Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy. Bioorg Med Chem Lett. 2021 Oct 15;50:128338. DOI:10.1016/j.bmcl.2021.128338 |
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