| Identification | Back Directory | [Name]
CyclopropanecarboxaMide, N-[3-(2-Methoxyethyl)-4,5-diMethyl-2(3H)-thiazolylidene]-2,2,3,3-tetraMethyl-, [N(Z)]- | [CAS]
959746-77-1 | [Synonyms]
A-836339
(A836339)
A-836339,A 836339,Cannabinoid Receptor,A836339,inhibit,Inhibitor
1-(tetrahydropyran-4-ylMethyl)-1H-indol-3-yl]-(2,2,3,5-tetraMethylcyclopropyl)Methanone
CyclopropanecarboxaMide, N-[3-(2-Methoxyethyl)-4,5-diMethyl-2(3H)-thiazolylidene]-2,2,3,3-tetraMethyl-, [N(Z)]- | [Molecular Formula]
C16H26N2O2S | [MDL Number]
MFCD17167006 | [MOL File]
959746-77-1.mol | [Molecular Weight]
310.46 |
| Chemical Properties | Back Directory | [Boiling point ]
388.4±44.0 °C(Predicted) | [density ]
1.14±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMSO: 5 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml; Methanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
-3.95±0.60(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
A-836339 is a synthetic cannabinoid (CB) which has a higher affinity for the peripheral CB2 receptor (Ki = 0.64 nM) over the central CB1 receptor (Ki = 270 nM). It displays analgesic, anti-inflammatory, and anti-hyperalgesic effects in mice. At higher doses, A-836339 also decreases spontaneous locomotor activities, consistent with CB1 activation. This product is intended for forensic and research applications. | [Uses]
A-836339, is a cannabinoid CB2 receptor-selective agonist; exhibits high potencies at CB(2) and selectivity over CB(1) receptors. Synthetic Cannabinoids. | [References]
[1] BETTY B YAO. Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging.[J]. Journal of Pharmacology and Experimental Therapeutics, 2009, 328 1: 141-151. DOI: 10.1124/jpet.108.145011
[2] S. MCGARAUGHTY. A CB2 receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: Contributions of spinal and peripheral CB2 receptors[J]. Neuroscience, 2009, 158 4: Pages 1652-1661. DOI: 10.1016/j.neuroscience.2008.11.015 |
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| Company Name: |
Candia Thamtech Company Limited
|
| Tel: |
0371-86615086 18203638366 0371-86159066 13526786601 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15771/0_EN.htm |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
|