| Identification | Back Directory | [Name]
Tadalafil-d3 | [CAS]
960226-55-5 | [Synonyms]
Tadalafil-d3
[2H3]-Tadalafil
PubChem ID: 46782966
Pyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione, 6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-(methyl-d3)-, (6R,12aR)-
Tadalafil D3Q: What is
Tadalafil D3 Q: What is the CAS Number of
Tadalafil D3 Q: What is the storage condition of
Tadalafil D3 Q: What are the applications of
Tadalafil D3 | [Molecular Formula]
C22H18N3O4 | [MDL Number]
MFCD04116200 | [MOL File]
960226-55-5.mol | [Molecular Weight]
388.396 |
| Chemical Properties | Back Directory | [Melting point ]
281-283°C | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), DMSO (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Unstable in Methanol | [InChI]
InChI=1/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21+/s3 | [InChIKey]
WOXKDUGGOYFFRN-PDIFIXMTNA-N | [SMILES]
c12c3ccccc3nc1[C@H](c1cc3OCOc3cc1)N1C(=O)CN(C)C(=O)[C@H]1C2 |&1:9,27,r| |
| Hazard Information | Back Directory | [Description]
Tadalafil-d3 is intended for use as an internal standard for the quantification of tadalafil (Item No. 14024) by GC- or LC-MS. Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50 = 1.2 nM).1 It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 μM), however, it does also inhibit PDE11 (IC50 = 11 nM). In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury.2 It also reduces development of tobacco smoke-induced emphysema and pulmonary hypertension in mice.3 Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction. | [Chemical Properties]
Tadalafil-d3 is White Solid
| [Uses]
Tadalafil is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor. | [Uses]
Tadalafil-d3 is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor. Intended for use as an internal standard for the quantification of Tadalafil by GC- or LC-mass spectrometry.
| [storage]
Store at -20°C | [References]
[1] GRAEME L CARD. Structural basis for the activity of drugs that inhibit phosphodiesterases.[J]. Structure, 2004, 12 12: 2233-2247. DOI: 10.1016/j.str.2004.10.004
[2] VANESSA DE FáTIMA LIMA PAIVA MEDEIROS. The renoprotective effect of oral Tadalafil pretreatment on ischemia/reperfusion injury in rats.[J]. Acta cirurgica brasileira, 2017, 32 2: 90-97. DOI: 10.1590/s0102-865020170201
[3] MICHAEL SEIMETZ. Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice.[J]. PLoS ONE, 2015: e0129327. DOI: 10.1371/journal.pone.0129327 |
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BOC Sciences Gold
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https://www.bocsci.com |
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