| Identification | Back Directory | [Name]
Crisnatol | [CAS]
96389-68-3 | [Synonyms]
770U-82
BW-A-770U
Crisnatol
Crisnatolum
Unii-2J71ur51ue
Crisnatol [inn]
Crisnatolum [latin]
2-((6-chrysenylmethyl)amino)-2-methyl-1,3-propanediol
2-(Chrysene-6-ylmethylamino)-2-methyl-1,3-propanediol
2-[(Chrysen-6-ylmethyl)amino]-2-methyl-1,3-propanediol
1,3-Propanediol, 2-((6-chrysenylmethyl)amino)-2-methyl- | [Molecular Formula]
C23H23NO2 | [MOL File]
96389-68-3.mol | [Molecular Weight]
345.43 |
| Hazard Information | Back Directory | [Uses]
Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts[1][2][3]. | [in vivo]
Crisnatol (25 mg/kg; p.o.; single dose) shows oral activity and shows stable metabolite profile extract of rat feces by autoradiography[2]. | [References]
[1] Adams DJ. In vitro pharmacodynamic assay for cancer drug development: application to crisnatol, a new DNA intercalator. Cancer Res. 1989 Dec 1;49(23):6615-20. PMID:1676660
[2] Patel DK, et al. Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Characterization of metabolites. Biochem Pharmacol. 1991 Jul 5;42(2):337-46. DOI:10.1016/0006-2952(91)90721-g
[3] Patel DK, et al. Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat. Drug Metab Dispos. 1991 Mar-Apr;19(2):491-7. PMID:1676660 |
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| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
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