| Identification | Back Directory | [Name]
dimethylaminohydroxypropoxytriamterene | [CAS]
96558-24-6 | [Synonyms]
RPH-2823
dimethylaminohydroxypropoxytriamterene
4-(3-Dimethylamino-2-hydroxy)-propoxytriamterene
1-(Dimethylamino)-3-[4-(2,4,7-triamino-6-pteridinyl)phenoxy]-2-propanol
2-Propanol, 1-(dimethylamino)-3-[4-(2,4,7-triamino-6-pteridinyl)phenoxy]- | [Molecular Formula]
C17H22N8O2 | [MDL Number]
MFCD01696978 | [MOL File]
96558-24-6.mol | [Molecular Weight]
370.41 |
| Chemical Properties | Back Directory | [Boiling point ]
690.8±65.0 °C(Predicted) | [density ]
1.404±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.73±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
RPH-2823, a basic triamterene derivative, induces a dose-dependent decrease in short-circuit current (SCC) and increase in transepithelial electrical resistance[1]. | [in vivo]
RPH 2823 (2.5 mumol/kg) can avoid the kaliuresis of 25 mumol/kg furosemide in male Wistar rats. RPH 2823 (1 mg/kg and 5 mg/kg, i.v.) has a terminal elimination half-life of 3 h. About 47% of the given dose are excreted unchanged with urine[2]. | [References]
[1] Kipnowski J, et al. Effects of standard diuretics and RPH 2823 on transepithelial Na+ transport in isolated frog skin. Klin Wochenschr. 1986;64(16):750-759. DOI:10.1007/BF01734343
[2] Priewer H, et al. Pharmacodynamics and pharmacokinetics of the basic triamterene analogue dimethylaminohydroxypropoxytriamterene. Arzneimittelforschung. 1985;35(11):1688-1691. PMID:4091871 |
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