| Identification | Back Directory | [Name]
ADENOSINE AMINE CONGENER (ADAC) | [CAS]
96760-69-9 | [Synonyms]
ADENOSINE AMINE CONGENER (ADAC)
Adenosine amine congener hydrate
N-[4-[2-[[4-[2-[(2-Aminoethyl)amino]-2-oxoethyl]phenyl]amino]-2-oxoethyl]phenyl]adenosine
Adenosine, N-[4-[2-[[4-[2-[(2-aminoethyl)amino]-2-oxoethyl]phenyl]amino]-2-oxoethyl]phenyl]-
N6-[4-[[[4-[[[(2-AMinoethyl)aMino]carbonyl]Methyl]-anilino]carbonyl]Methyl]phenyl]adenosine hydrate
ADAC, N6-[4-[[[4-[[[(2-Aminoethyl)amino]carbonyl]methyl]-anilino]carbonyl]methyl]phenyl]adenosine hydrate
N-(2-Aminoethyl)-2-(4-(2-(4-((9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)amino)phenyl)acetamido)phenyl)acetamide | [Molecular Formula]
C28H32N8O6 | [MDL Number]
MFCD11045962 | [MOL File]
96760-69-9.mol | [Molecular Weight]
576.6 |
| Chemical Properties | Back Directory | [density ]
1.56±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
0.1 M acetic acid: 12 mM | [form ]
solid | [pka]
13.11±0.70(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects[1][2]. | [in vivo]
Adenosine amine congener (25-300?μg/kg/day; intraperitoneal injection; daily; for 5 days; male Wistar rats) treatment is most effective in the first 24 hours after noise exposure at doses >50?μg/kg, providing up to 21?dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner[1]. | Animal Model: | Male Wistar rats (8-10 weeks old) treated with noise exposure[1] | | Dosage: | 25 μg/kg/day, 50 μg/kg/day, 100 μg/kg/day, 200 μg/kg/day, and 300?μg/kg/day | | Administration: | Intraperitoneal injection; daily; for 5 days | | Result: | Most effective in the first 24 hours after noise exposure at doses >50?μg/kg, and provided up to 21?dB protection (averaged across 8-28?kHz).
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| [storage]
Store at -20°C | [References]
[1] Vlajkovic SM, et al. Adenosine amine congener as a cochlear rescue agent. Biomed Res Int. 2014;2014:841489. DOI:10.1155/2014/841489
[2] Vlajkovic SM, et al. Adenosine amine congener mitigates noise-induced cochlear injury. Purinergic Signal. 2010 Jun;6(2):273-81. DOI:10.1007/s11302-010-9188-5 |
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https://www.bocsci.com |
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