| Identification | Back Directory | [Name]
2,21-Cycloaspidospermidine-3-carboxylic acid, 15-[(3α,14α,16α)-14,15-dihydro-20-hydroxyeburnamenin-14-yl]-, methyl ester, (3β,5α,12R,19α)- | [CAS]
96935-25-0 | [Synonyms]
2,21-Cycloaspidospermidine-3-carboxylic acid, 15-[(3α,14α,16α)-14,15-dihydro-20-hydroxyeburnamenin-14-yl]-, methyl ester, (3β,5α,12R,19α)- | [Molecular Formula]
C40H48N4O3 | [MOL File]
96935-25-0.mol | [Molecular Weight]
632.84 |
| Hazard Information | Back Directory | [Description]
Kopsoffinol is a bisindole alkaloid that has been shown to have in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells. | [Uses]
Kopsoffinol, a bisindole alkaloid, shows in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells[1]. | [References]
[1] "Wai-Sum Yap, et al. Aspidofractinine and Eburnane Alkaloids from a North Borneo Kopsia. Ring-Contracted, Additional Ring-Fused, and Paucidactine-Type Aspidofractinine Alkaloids from K. pauciflora. J Nat Prod
. 2016 Jan 22;79(1):230-9." DOI:10.1021/acs.jnatprod.5b00992 |
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