| Identification | Back Directory | [Name]
1-Aziridinecarboxylicacid,1,1-dimethylethylester(9CI) | [CAS]
97308-23-1 | [Synonyms]
N-Boc-aziridine
1-Boc-aziridine
N-(tert-butoxycarbonyl)aziridine
tert-butyl aziridine-1-carboxylate
1-Aziridinecarboxylicacid tert-butyl ester
1-Aziridinecarboxylic acid, 1,1-diMethylethyl ester
1-Aziridinecarboxylicacid,1,1-dimethylethylester(9CI)
1-Aziridinecarboxylicacid,1.1-dimethylethylester(qci)
1-Aziridinecarboxylicacid,1,1-dimethylethylester(9Cl) | [Molecular Formula]
C7H13NO2 | [MDL Number]
MFCD16036961 | [MOL File]
97308-23-1.mol | [Molecular Weight]
143.18 |
| Chemical Properties | Back Directory | [Boiling point ]
174.8±9.0 °C(Predicted) | [density ]
1.088±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [pka]
-3.23±0.20(Predicted) | [Appearance]
Colorless to light yellow Liquid | [InChI]
InChI=1S/C7H13NO2/c1-7(2,3)10-6(9)8-4-5-8/h4-5H2,1-3H3 | [InChIKey]
VBYPJHLRWKGNAI-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CC1 |
| Hazard Information | Back Directory | [Uses]
N-(tert-Butoxycarbonyl)aziridine is a useful reagent for organic synthesis and other chemical processes. It is used as a reagent in the preparation of substituted indolines and carbazoles by benzyne-mediated cyclization-functionalization. | [Synthesis]
Example 47 Synthesis of N-Boc aziridine 166: To a solution of aziridine 165 (125 mg, 0.49 mmol) in dichloromethane (7 mL) was added triethylamine (70 μL), DMAP (catalytic amount), and di-tert-butyl dicarbonate (Boc anhydride, 113 mg, 0.52 mmol) in sequence. The reaction mixture was stirred at room temperature for 1 h and then concentrated under reduced pressure to remove the solvent. The residue was purified by fast column chromatography (eluent: hexane solution of 40% ethyl acetate) to afford 154 mg (88% yield) of the title compound, N-Boc aziridine 166, as a light colored oil.1H NMR (CDCl3, 300 MHz): δ 6.82 (m, 1H); 4.47 (br m, 1H); 4.23 (t, 2H, J = 4.7 Hz); 3.81 (t, 2H, J = 4.7 Hz); 3.75 (s, 3H); 3.00 (br d, 1H, J = 18.0 Hz); 2.90-2.85 (m, 2H); 2.65-2.55 (m, 1H); 2.10 (s, 3H); 1.44 (s, 9H). | [References]
[1] Chemical Communications, 1998, # 2, p. 253 - 254
[2] Patent: US6534037, 2003, B1
[3] Patent: US5952375, 1999, A
[4] Patent: US5763483, 1998, A
[5] Patent: US2004/53999, 2004, A1 |
|
| Company Name: |
Tetranov Biopharm
|
| Tel: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
|