| Identification | Back Directory | [Name]
Aristolactam AIIIa | [CAS]
97399-91-2 | [Synonyms]
Aristolactam AIIIa
PubChem ID: 10356352
Aristololactam A IIIa
Dibenz[cd,f]indol-4(5H)-one, 2,9-dihydroxy-1-methoxy- | [Molecular Formula]
C16H11NO4 | [MDL Number]
MFCD17214810 | [MOL File]
97399-91-2.mol | [Molecular Weight]
281.26 |
| Chemical Properties | Back Directory | [Melting point ]
>300 °C | [Boiling point ]
521.1±50.0 °C(Predicted) | [density ]
1.541±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
8.63±0.20(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells[1]. | [target]
CDK | MAPK | [References]
[1] Chia YC, et al. Aristolactams and dioxoaporphines from Fissistigma balansae and Fissistigma oldhamii. J Nat Prod. 2000 Aug;63(8):1160-3. DOI:10.1021/np000063v |
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