| Identification | Back Directory | [Name]
HUMAN IL-1ALPHA | [CAS]
97599-22-9 | [Synonyms]
HUMAN EP
HUMAN LAF
HUMAN LEM
HUMAN MCF
HIL-1ALPHA
HUMAN IL-1A
HUMAN IL-1ALPHA
REC IL-1A (HUMAN)
IL-1 ALPHA, HUMAN
REC IL-1ALPHA (HUMAN)
HUMAN HEMATOPOIETIN-1
RECOMBINANT HUMAN IL-1A
Endogenous Pyrogen (EP)
HUMAN ENDOGENOUS PYROGEN
HUMAN INTERLEUKIN-1 ALPHA
INTERLEUKIN-1ALPHA, HUMAN
REC INTERLEUKIN-1A (HUMAN)
HUMAN MONONUCLEAR CELL FACTOR
REC INTERLEUKIN-1ALPHA (HUMAN)
Lymphocyte-activating factor (LAF)
HUMAN LYMPHOCYTE-ACTIVATING FACTOR
HUMAN LEUKOCYTE ENDOGENOUS MEDIATOR
INTERLEUKIN-1ALPHA, HUMAN, RECOMBINANT, E COLI
INTERLEUKIN-1ALPHA (IL-1ALPHA), HUMAN, RECOMBINANT | [MDL Number]
MFCD00131398 |
| Hazard Information | Back Directory | [Uses]
IL-1α (interleukin) is one of the three isoforms of IL-1, the other two being IL-1β and IL-1Rα. It is a proinflammatory macrophage cytokine. IL-1α is produced de novo and can either be actively secreted or can be released passively by apoptotic cells. This gene is localized to human chromosome 2q13–2q14.1.
Recombinant human IL-1α is an 18.0 kDa protein containing 159 amino acid residues. | [Biological Activity]
IL-1α (interleukin) and IL-1β bind with IL-1 receptor and function as proinflammatory cytokineswhereas IL-1Rα competes to bind with IL-1R but is not proinflammatory. IL-1α can function as an intracrine molecule or as a transcription factor. IL-1 plays a major role in ischemic brain damageas the inactivation of both IL-1α and IL-1β lead to significant suppression in brain injury. Howeverinactivation of only IL-1α does not have much influence on overall damage due to some compensatory modifications in the IL-1 system. A hospital-based case-control study showed th at rs3783553 variant in this gene is linked with reduced risk of breast cancer. Tumor cell production of IL-1α helps their transmigration across the endotheliumand the expression of IL-1α is linked with distant metastasis in patients with head and neck squamous cell carcinoma. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Antibodies com
|
| Tel: |
65-6980-8108 65698081 |
| Website: |
www.antibodies.com |
| Company Name: |
Fedprotein
|
| Tel: |
13041401126; 13041401126 |
| Website: |
https://www.fedprotein.com |
| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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