| Identification | Back Directory | [Name]
FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride | [CAS]
97612-24-3 | [Synonyms]
Eticlopride hydrochl
S(-)-ETICLOPRIDE HYDROCHLORIDE (POTENT A ND SELECTIVE D2 DOPAMINE
3-Chloro-5-ethyl-N-[[(2S)-1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxy-benzamidehydrochloride
FLB 131, S-(-)-3-Chloro-5-ethyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-hydroxy-2-methoxybenzamide hydrochloride | [Molecular Formula]
C17H26Cl2N2O3 | [MDL Number]
MFCD00055132 | [MOL File]
97612-24-3.mol | [Molecular Weight]
377.31 |
| Chemical Properties | Back Directory | [Melting point ]
144-146 °C(Solv: acetone (67-64-1)) | [storage temp. ]
Desiccate at RT | [solubility ]
H2O: soluble >10mg/mL | [form ]
powder | [color ]
off-white | [optical activity]
[α]27/D 7.2°, c = 0.3 in methanol(lit.) | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Uses]
Dopamine receptor antagonist | [Uses]
S-(?)-Eticlopride hydrochloride has been used in astrocyte-neuron coculture and functional magnetic resonance imaging (fMRI) experiments. | [Biological Activity]
Selective dopamine D 2 /D 3 receptor antagonist (K i values are 0.50 and 0.16 nM respectively). Antipsychotic. | [Biochem/physiol Actions]
Potent and selective D2 dopamine receptor antagonist. Eticlopride is highly specific for DAD2?receptors than pimozide or haloperidol. The gene encoding the D2 dopamine receptor (DRD2) is linked with a several disorders including Parkinson′s disease, schizophrenia, and susceptibility to alcoholism. | [in vivo]
Eticlopride (10 mg/kg, i.p.) hydrochloride blocks normal vessel morphologyc restored by DA in orthotopic PC3 and HT29 tumor-bearing mice[2].
Eticlopride (0.01 or 0.02 mg/kg, i.p.) hydrochloride alleviates cognitive deficits produced by Quinpirole (HY-B1752) in rats[4].
| Animal Model: | Sprague-Dawley rats treated with Ruinpirole (1 mg/kg) from postnatal days 1 to 21[4] | | Dosage: | 0.01 or 0.02 mg/kg | | Administration: | i.p. | | Result: | Alleviated cognitive deficits produced by neonatal quinpirole treatment in both male and female rats on the place version of the MWT, as well as in males tested on the match-to-place version of the MWT (MWT tested on P22 to P28). |
| [IC 50]
D2 Receptor: 0.09 nM (Ki) | [storage]
room temperature (desiccate) |
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