| Identification | Back Directory | [Name]
Y 516 | [CAS]
98043-60-8 | [Synonyms]
Y 516
Cremin
mosapramine hydrochloride
Clospipramine hydrochloride
Mosapramine dihydrochloride
1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one
1'-[3-(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]hexahydro-spiro[imidazo[1,2-a]pyridine-3(2H),4'-piperidin]-2-one dihydrochloride
Spiro[imidazo[1,2-a]pyridine-3(2H),4'-piperidin]-2-one, 1'-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]hexahydro-, dihydrochloride (9CI) | [Molecular Formula]
C28H35ClN4O | [MDL Number]
MFCD00867739 | [MOL File]
98043-60-8.mol |
| Hazard Information | Back Directory | [Description]
Clospipramine hydrochloride is a metabolite of clocapramine reportedly useful in the
treatment of schizophrenia. In schizophrenic patients, its clinical efficacy and overall
safety rating were not significantly different from clocapramine. However, at a lower
dosage, clospipramine hydrochloride was more effective than clocapramine. | [Originator]
Yoshitomi (Japan) | [Definition]
ChEBI: Mosapramine dihydrochloride is a racemate. It has a role as a dopaminergic antagonist and a second generation antipsychotic. | [Brand name]
Cremin |
| Safety Data | Back Directory | [Toxicity]
LD50 in male and female mice (mg/kg): 1008, 1293 orally; 74, 116 i.p.; 1147, 1264 s.c. (Horizoe) |
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