| Identification | Back Directory | [Name]
Benzene, 4-broMo-2-iodo-1-Methoxy- | [CAS]
98273-59-7 | [Synonyms]
Anisole, 4-bromo-2-iodo-
4-BroMo-2-iodo-1-Methoxybenzene
4-Bromo-2-iodophenyl methyl ether
Benzene, 4-broMo-2-iodo-1-Methoxy-
4-Bromo-2-iodo-1-methoxybenzene, 4-Bromo-2-iodophenyl methyl ether | [Molecular Formula]
C7H6BrIO | [MDL Number]
MFCD13186707 | [MOL File]
98273-59-7.mol | [Molecular Weight]
312.93 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-bromo-2-iodo-1-methoxybenzene from 4-bromoanisole: To a stirring solution of 4-bromoanisole (1 mmol) in dichloromethane (CH2Cl2) or 1,2-dichloroethane ((CH2Cl)2) (0.1 M) was added sequentially Ph3PAuNTf2 (0.025 mmol, 19 mg; if using the 2:1 complex of Ph3PAuNTf2 with toluene) and N-iodosuccinimide (NIS, 1.1 mmol, 248 mg). The reaction mixture was stirred at room temperature or reacted under reflux conditions until complete conversion of the feedstock was confirmed by thin layer chromatography (TLC) monitoring. Upon completion of the reaction, the solvent was evaporated under reduced pressure and the resulting crude product was purified by fast column chromatography using different ratios of hexane and ethyl acetate (EtOAc) as eluents, resulting in pure 4-bromo-2-iodo-1-methoxybenzene. | [References]
[1] Journal of the American Chemical Society, 2008, vol. 130, # 2, p. 472 - 480
[2] Synlett, 1998, # 3, p. 286 - 288
[3] Synlett, 1998, # 5, p. 534 - 536
[4] Journal of Organic Chemistry, 1999, vol. 64, # 8, p. 2883 - 2889
[5] Bulletin of the Chemical Society of Japan, 1999, vol. 72, # 10, p. 2351 - 2356 |
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