| Identification | Back Directory | [Name]
gamma-kainylglutamic acid | [CAS]
98394-38-8 | [Synonyms]
gamma-Kan-glu
gamma-kainylglutamic acid
N-<<<2'S-(2'α,3'β,4'β)>-2'-carboxy-4'-(1''-methylethenyl)-3'-pyrrolidinyl>acetyl>-L-glutamic acid | [Molecular Formula]
C15H22N2O7 | [MOL File]
98394-38-8.mol | [Molecular Weight]
342.35 |
| Hazard Information | Back Directory | [Description]
gamma-Kainylglutamic acid is a selective antagonist of amino acid induced neuroexcitation. | [Uses]
γ-Kainylglutamic acid (γ-Kainic acid-glutamic acid), a dipeptide derived from kainic and L-Glutamic acids, is a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties. γ-Kainylglutamic acid inhibits the stimulation of Na+ fluxes induced in brain slices by the neuroexcitant N-methyl-D-aspartic acid. γ-Kainylglutamic acid is also effective in protecting mice from picrotoxin-induced convulsions with an EC50 value of 0.17 μmol[1]. | [References]
[1] Goldberg O, et al. A dipeptide derived from kainic and L-glutamic acids: a selective antagonist of amino acid induced neuroexcitation with anticonvulsant properties. J Med Chem. 1985 Dec;28(12):1957-8. DOI:10.1021/jm00150a034 |
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