| Identification | Back Directory | [Name]
S(-)-BAY K 8644 | [CAS]
98625-26-4 | [Synonyms]
R-5417
BAY-r-5417
S(-)-BAY K 8644
Bay-K-8644 ((S)-(-)-)
S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO
methyl (-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]pyridine-3-carboxylate
(4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester
(4S)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
s-(-)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
[4S,(-)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-, methyl ester, (4S)- | [Molecular Formula]
C16H15F3N2O4 | [MDL Number]
MFCD00153769 | [MOL File]
98625-26-4.mol | [Molecular Weight]
356.3 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: slightly soluble
| [form ]
solid
| [color ]
yellow
| [Water Solubility ]
H2O: slightly soluble
ethanol: soluble (Organic solutions are stable for at least 20 days at RT.) |
| Hazard Information | Back Directory | [Uses]
(S)-(-)-Bay K8644 has been used as a L-type calcium channel (LTCC) agonist in the suprachiasmatic nucleus (SCN) slices. It has also been used as a LTCC agonist to induce arrhythmia?in rats. | [Definition]
ChEBI: (S)-Bay-K-8644 is a methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate in which the 4-position has (S)-configuration. It is an enantiomer of a (R)-Bay-K-8644. | [General Description]
(S)-(-)-Bay K8644, a dihydropyridine compound is a Ca2+?channel activator. It is an enantiomer of Bay K 8644. | [Biological Activity]
L-type Ca 2+ -channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo . Enantiomer of (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ). | [Biochem/physiol Actions]
(S)-(-)-Bay K8644 enhances Ca2+ current, whereas the (+)-Bay K 8644 is a weak Ca2+ channel antagonist. Bay K 8644 is lipophilic and it effectively scavenges superoxide anions. | [storage]
Store at +4°C |
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