| Identification | Back Directory | [Name]
Bis-aminooxy-PEG2 | [CAS]
98627-71-5 | [Synonyms]
Bis-aminooxy-PEG2
1,8-diaminooxy-3,6-dioxaoctane
Hydroxylamine, O,O'-[1,2-ethanediylbis(oxy-2,1-ethanediyl)]bis- | [Molecular Formula]
C6H16N2O4 | [MDL Number]
MFCD00519242 | [MOL File]
98627-71-5.mol | [Molecular Weight]
180.2 |
| Chemical Properties | Back Directory | [Boiling point ]
339.7±32.0 °C(Predicted) | [density ]
1.123±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DMF | [form ]
Liquid | [pka]
4.51±0.70(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Bis-aminooxy-PEG2 is a homobifunctional PEG linker with two aminooxy groups. The aminooxy group is reactive with aldehyde to form an oxime bond. If a reductant is applied, it will form a hydroxylamine linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
Bis-aminooxy-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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