| Identification | Back Directory | [Name]
TANDOSPIRONE HCl | [CAS]
99095-10-0 | [Synonyms]
TANDOSPIRONE HCl
Reaxys ID: 5370496
4,7-METHANO-1H-ISOINDOLE-1,3(2H)-DIONE, HEXAHYDRO-2-[4-[4-(2-PYRIMIDINYL)-1-PIPERAZINYL]BUTYL]-, HCL, (3AR,4S,7R,7AS)-REL-
4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyriMidinyl)-1-piperazinyl]butyl]-, hydrochloride, (3aR,4S,7R,7aS)-rel- | [Molecular Formula]
C21H30ClN5O2 | [MDL Number]
MFCD28400906 | [MOL File]
99095-10-0.mol | [Molecular Weight]
419.95 |
| Hazard Information | Back Directory | [Uses]
Tandospirone Hydrochloride is a 5-HT receptor agonist that is used for treating anxiety and depression. | [in vivo]
Tandospirone (SM-3997) hydrochloride (10-80 mg/kg; i.p.) inhibits freezing behavior in the conditioned fear stress-induced freezing behavior rat model[3].
Tandospirone hydrochloride exhibits the anxiolytic effect dependent on the plasma concentration of at 0.5 hours but not 4 hours[3]. | Animal Model: | Seven-week-old male Sprague-Dawley rats (260-300 g), conditioned fear stress-induced freezing behavior rat model[3] | | Dosage: | 10 mg/kg, 20 mg/kg, 40 mg/kg, 80 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Inhibited freezing behavior in a dose-dependent manner. |
| [IC 50]
5-HT1A Receptor: 27 nM (Ki) | [storage]
Store at +4°C |
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