| Identification | Back Directory | [Name]
E 0747 | [CAS]
99599-78-7 | [Synonyms]
E 0747
L-29065
6-chloro-2,2-dimethyl-1'-[3-(4-hydroxypiperidino)propyl]spiro[chroman-4,4'-imidazolidine]-2',5'-dione
6-Chloro-2,3-dihydro-1'-[3-(4-hydroxy-1-piperidinyl)propyl]-2,2-dimethylspiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione | [Molecular Formula]
C21H28ClN3O4 | [MDL Number]
MFCD01939145 | [MOL File]
99599-78-7.mol | [Molecular Weight]
421.918 |
| Hazard Information | Back Directory | [Description]
E 0747 is an antiarrhythmic agent of class 1C type of the Vaughan Williams' classification. E-0747 suppresses arrhythmia by inhibiting Na channels of cardiac cells and is expected to become a clinically useful antiarrhythmic drug. | [Uses]
E-0747 is an antiarrhythmic drug that inhibits arrhythmias by inhibiting Na[+] channels in cardiomyocytes[1]. | [References]
[1] Mitsuhashi H, et al. Antiarrhythmic effects of a new drug, E-0747, on canine ventricular arrhythmia models. Jpn J Pharmacol. 1987 Jun;44(2):155-62. DOI:10.1254/jjp.44.155 |
|
|