| Identification | Back Directory | [Name]
19-(ethyldithio)androst-4-ene-3,17-dione | [CAS]
99957-90-1 | [Synonyms]
ORG-30958
19-(ethyldithio)androst-4-ene-3,17-dione | [Molecular Formula]
C21H30O2S2 | [MDL Number]
MFCD00902865 | [MOL File]
99957-90-1.mol | [Molecular Weight]
378.59 |
| Hazard Information | Back Directory | [Uses]
Org30958 is a potent aromatase inhibitor in vivo. | [in vivo]
Besides inhibition of cornification of vaginal epithelium Org30958 (ORG 30958) decreases ovarian aromatase and plasma E2 levels in DHEAS-treated hypophysectomized rats. Plasma estradiol levels are also lowered by Org30958 in dogs which are treated with pregnant mare serum gonadotrophin in order to induce pro-estrus. Org30958 displays much less than 1/400th of the androgenic activity of testosterone propionate in immature castrated rats and appears to be devoid of estrogenic and anti-estrogenic activity in ovariectomized mature rats. A twice daily dose of 1.5 mg Org30958/kg postpones ovulation in mature female rats[1]. | [IC 50]
Aromatase | [References]
[1] Geelen JA, et al. Selection of 19-(ethyldithio)-androst-4-ene-3,17-dione (ORG 30958): a potent aromatase inhibitor in vivo. J Steroid Biochem Mol Biol. 1991 Feb;38(2):181-8. DOI:10.1016/0960-0760(91)90124-n |
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