103404-90-6

中文名称 2-羟基-D-谷氨酸

英文名称 D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT

CAS 103404-90-6

分子式 C5H6Na2O5

分子量 192.08

MOL 文件 103404-90-6.mol

更新日期 2025/03/14 10:16:32

103404-90-6 结构式

基本信息物理化学性质安全数据图谱信息 2-羟基-D-谷氨酸价格(试剂级) 常见问题列表

基本信息

中文别名

2-羟基-D-谷氨酸
D-A-羟基戊二酸二钠
2-羟基-D-谷氨酸钠
D-Α-羟基戊二酸二钠盐
(R)-2-羟基戊二酸钠
D-2-羟基戊二酸二钠盐
(R)-2-羟基戊二酸二钠盐
2-羟基-D-谷氨酸二钠盐
(R)-2-羟基戊二酸二钠盐, D-A-羟基戊二酸二钠
D-2-HYDROXYPENTANEDIOIC ACID鈥NA+

英文别名

sodiuM 2-hydroxypentanedioate
(r)-2-hydroxypentanedioic acid
Disodium (R)-2-hydroxyglutarate
(2R)-2-Hydroxypentanedioic acid
D-A-HYDROXYGLUTARIC ACID DISODIUM
SodiuM (R)-2-hydroxypentanedioate
D-α-Hydroxyglutaric acid disodium
isodium,(2R)-2-hydroxypentanedioate
D-ALPHA-HYDROXYGLUTARIC ACID DISODIU
disodium:(2R)-2-hydroxypentanedioate

所属类别

生物化工：谷氨酸类衍生物

物理化学性质

熔点>291°C (dec.)

储存条件-20°C

溶解度PBS (pH 7.2): 10 mg/ml

形态结晶固体

颜色White to light yellow

旋光性 (optical activity)[α]/D 8.5±1.5°, c = 1 in NaOH

水溶解性溶于水至100mM

BRN5318041

稳定性吸湿性

InChIKeyDZHFTEDSQFPDPP-HWYNEVGZSA-L

安全数据

WGK Germany3

海关编码29181990

图谱信息

2-羟基-D-谷氨酸(103404-90-6)质谱(MS)

2-羟基-D-谷氨酸价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/02/08	HY-100542	2-羟基-D-谷氨酸 D-α-Hydroxyglutaric acid disodium	103404-90-6	5 mg	300元
2025/02/08	HY-100542	2-羟基-D-谷氨酸 D-α-Hydroxyglutaric acid disodium	103404-90-6	10mg	480元
2025/02/08	HY-100542	2-羟基-D-谷氨酸 D-α-Hydroxyglutaric acid disodium	103404-90-6	10mM * 1mLin Water	528元

常见问题列表

生物活性

Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium)是一种竞争性α-ketoglutarate-dependent dioxygenases抑制剂，其 Ki值为10.87 ± 1.85 mM。

靶点

Target	Value
α-ketoglutarate-dependent dioxygenase

体外研究

在U-87MG细胞中，(R)-2-Hydroxyglutarate作为α-KG的弱拮抗剂抑制α-KG依赖性组蛋白脱甲基化酶，并增加H3K9和H3K79的二甲基化作用。此外，(R)-2-Hydroxyglutarate抑制ATP合酶与mTOR信号，因此引起生长阻滞和肿瘤细胞杀伤。

体内研究

D-α-Hydroxyglutaric acid strongly inhibits glucose utilization, CO ₂ production and the respiratory chain in rat cerebral cortex and human skeletal muscle, as well as in submitochondrial particles from bovine heart, suggesting an impairment of the aerobic metabolism.
D-α-Hydroxyglutaric acid has also been proposed as an endogenous excitotoxic organic acid because it significantly decreased cell viability in neuronal cultures from chick embryo telencephalons and from neonatal rat hippocampus through stimulation of specific NMDA glutamate receptors.
D-α-Hydroxyglutaric acid (0.01-1 mM) significantly increases chemiluminescence and thiobarbituric acid-reactive substances (TBA-RS) and decreased total antioxidant reactivity (TAR) values in the cortical supernatants in 30-day-old-rats.