109358-46-5
中文名称
BOC-LEU-ARG-ARG-AMC · 2 HCL
英文名称
Boc-Leu-Arg-Arg-AMC . 2 HCl
CAS
109358-46-5
分子式
C33H52N10O7
分子量
700.83
MOL 文件
109358-46-5.mol
更新日期
2025/12/25 09:15:10
109358-46-5 结构式
基本信息
英文别名
Boc-LRR-AMCBoc-Leu-Arg-Arg-AMC . 2 HCl
N-[(1,1-Dimethylethoxy)carbonyl]-L-leucyl-L-arginyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide
tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-(4-methyl-2-oxochromen-7-yl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
所属类别
生物化工：氨基酸物理化学性质
密度1.34±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度可溶于DMSO（少许）、甲醇（少许）
酸度系数(pKa)11.34±0.46(Predicted)
形态固体
颜色白色至灰白色
序列Boc-Leu-Arg-Arg-AMC
稳定性吸湿性
应用领域
用途一
Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core. Upon enzymatic cleavage by the 26S proteasome or 20S proteolytic core, amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify 26S proteasome or 20S proteolytic core trypsin-like activity. AMC displays excitatioemission maxima of 340-360/440-460 nm, respectively.