110368-33-7

基本信息
中文别名
化合物CH55化合物 T14946
英文别名
CH 554-[(E)-3-(3,5-Di-tert-butylphenyl)-3-oxo-1-propenyl]benzoic acid
4-[(E)-3-[3,5-Bis(tert-butyl)phenyl]-3-oxo-1-propenyl]benzoic acid
(E)-4-(3-(3,5-Bis(1,1-dimethylethyl)phenyl)-3-oxo-1-propenyl)benzoic acid
4-[(E)-3-[3,5-Bis(1,1-dimethylethyl)phenyl]-3-oxo-1-propenyl]benzoic acid
4-[(1E)-3-[3,5-BIS(1,1-DIMETHYLETHYL)PHENYL]-3-OXO-1-PROPENYL]BENZOIC ACID
Benzoic acid, 4-(3-(3,5-bis(1,1-dimethylethyl)phenyl)-3-oxo-1-propenyl)-, (E)-
Benzoic acid, 4-[(1E)-3-[3,5-bis(1,1-dimethylethyl)phenyl]-3-oxo-1-propen-1-yl]-
物理化学性质
熔点202-203.5 °C
沸点509.5±50.0 °C(Predicted)
密度1.085±0.06 g/cm3(Predicted)
储存条件Store at RT
溶解度DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 5 mg/ml
酸度系数(pKa)4.09±0.10(Predicted)
形态结晶固体
颜色White to light yellow
稳定性感光
CH 55价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2025/05/22 | HY-107397 | Ch55 | 110368-33-7 | 1 mg | 545元 |
2025/05/22 | HY-107397 | Ch55 | 110368-33-7 | 10 mM * 1 mLin DMSO | 949元 |
2025/05/22 | HY-107397 | CH 55 Ch55 | 110368-33-7 | 5mg | 1184元 |
常见问题列表
生物活性
Ch55 是一种有效的合成类维生素 A。Ch55 与 RAR-α 和 RAR-β 受体具有高亲和力。Ch55 对细胞视黄酸结合蛋白 (CRABP) 的亲和力较低。Ch55 是 HL60 细胞分化的有效诱导物,EC50 为 200 nM,可用于癌症的研究。靶点
RARα
|
RARβ
|
体外研究
Ch55 inhibits squamous cell differentiation of rabbit tracheal epithelial cells by inhibiting type I transglutaminase activity (EC 50 = 0.02 nM) and increasing cholesterol sulfate levels (EC 50 = 0.03 nM). Ch55 also induce differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC 50 s = 0.26 and 0.5 nM, respectively), and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC 50 = 1 nM).