1135278-54-4
中文名称
化合物 T10781
英文名称
CGP 78608 hydrochloride
CAS
1135278-54-4
分子式
C11H14BrClN3O5P
分子量
414.58
MOL 文件
1135278-54-4.mol
1135278-54-4 结构式
常见问题列表
生物活性
CGP 78608 hydrochlorid 是 NMDA 受体甘氨酸结合位点的一种高效选择性拮抗剂，IC50 为 6 nM。CGP 78608 作为 GluN1/GluN3A 介导的甘氨酸电流的增强剂，EC50 值为 26.3 nM。具有抗惊厥活性。体外研究
CGP-78608 hydrochloride decreases glycine sensitivity of GluN1/GluN3A receptors through an inter-subunit allosteric effect between GluN1 and GluN3A agonist-binding domain (ABD) sites.
CGP 78608 hydrochloride reduces or abolishes ammonia-dependent cGMP synthesis which is a causative factor of ammonia neurotoxicity.
体内研究
CGP-78608 hydrochloride displays potent anticonvulsant effects after i.p. administration in the electroshock-induced convulsions assay in mice.