114778-60-8
中文名称
114778-60-8
英文名称
9-(3-hydroxypropoxy)guanine
CAS
114778-60-8
分子式
C8H11N5O3
分子量
225.2
MOL 文件
114778-60-8.mol
114778-60-8 结构式
基本信息
中文别名
化合物 T10615 英文别名
9-(3-hydroxypropoxy)guanine6H-Purin-6-one, 2-amino-1,9-dihydro-9-(3-hydroxypropoxy)-
常见问题列表
生物活性
BRL44385 有效且选择性地抑制单纯疱疹病毒 1 型和 2 型 (HSV-1 和 HSV-2)，水痘带状疱疹病毒 (VZV) 和 Epstein-Barr 病毒 (EBV) 复制。靶点
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HSV-1
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HSV-2
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体内研究
BRL44385 is a selective antiherpesvirus agent. Following oral administration, BRL 55792 is very well absorbed and provides high and prolonged concentrations of BRL44385 in the blood. In mice 15 min and 60 min after administration of a single oral dose of BRL 55792, the concentrations of BRL44385 in the blood are considerably higher than those obtain after oral administration of either BRL44385 or BRL46720 and the bioavailability of BRL 44385 from oral BRL 55792 is 66% of that achieves with the same dose of the sodium salt of BRL44385 administered intravenously.