115150-59-9
中文名称
ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2
英文名称
(ARG6,D-TRP7,9,N-ME-PHE8)-SUBSTANCE P (6-11)
CAS
115150-59-9
分子式
C49H66N12O6S
分子量
951.19
MOL 文件
115150-59-9.mol
更新日期
2025/06/03 11:35:27
115150-59-9 结构式
基本信息
中文别名
拮抗剂G TFA盐化合物 T20481
拮抗剂G 三氟乙酸盐
拮抗剂多肽ANTAGONIST G
P物质肽[ARG6, DTRP7, 9, N-(NME)PHE8]- SUBSTANCE P(6-11)
英文别名
(arg6ANTAGONIST G
ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2
H-ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2
Arg-D-Trp-N-Methyl-Phe-D-Trp-Leu-Met-NH2
(ARG6,D-TRP7,9,N-ME-PHE8)-SUBSTANCE P (6-11)
Substance P, fragment 6-11, [Arg6, D-Trp7,9, NMePhe8]
AntagonistG, Arg-D-Trp-N-Methyl-Phe-D-Trp-Leu-Met-NH2
[Arg6, D-Trp7,9, N-Me-Phe8]-SubstanceP fragment6-11
arginyl-tryptophyl-n-methylphenylalanyl-tryptophyl-leucyl-methioninamide
ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-P1185 | ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2 Antagonist G | 115150-59-9 | 5mg | 1800元 |
| 2025/05/22 | HY-P1185 | Antagonist G | 115150-59-9 | 10 mg | 2900元 |
| 2023/03/20 | HY-P1185 | ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2 Antagonist G | 115150-59-9 | 1mg | 1500元 |
常见问题列表
生物活性
Antagonist G 是有效的后叶加压素 (vasopressin) 的拮抗剂。Antagonist G 也是弱的 GRP 和缓激肽的弱拮抗剂。Antagonist G 可诱导 AG-1 的转录，是癌细胞对化疗增敏。体外研究
Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells.
Antagonist G activates JNK1 in SCLC cells.
Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%.
Cell Viability Assay
| Cell Line: | SCLC cell lines NCI-H69, NCI-H510 and CHO-K1 cells. |
| Concentration: | 0-100 μM. |
| Incubation Time: | 24 h. |
| Result: | Inhibited cell growh. |