1179347-65-9

中文名称 5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile

英文名称 5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile

CAS 1179347-65-9

分子式 C21H14N2O2

分子量 326.35

MOL 文件 1179347-65-9.mol

1179347-65-9 结构式

基本信息物理化学性质安全数据 5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile价格(试剂级) 常见问题列表

基本信息

中文别名

化合物MT 63-78

英文别名

MT 63-78
5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile
1H-Indole-3-carbonitrile, 5-(2',6'-dihydroxy[1,1'-biphenyl]-4-yl)-

物理化学性质

储存条件4°C, protect from light

形态Solid

颜色Light yellow to brown

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P280-P305+P351+P338

5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/05/22	HY-W058849	MT 63-78	1179347-65-9	1 mg	800元
2025/05/22	HY-W058849	5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile MT 63-78	1179347-65-9	5mg	2100元
2025/05/22	HY-W058849	5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile MT 63-78	1179347-65-9	10mg	3500元

常见问题列表

生物活性

MT 63-78 是一种有效的直接 AMPK 激活剂，EC50 为 25 μM。M 63-78 还诱导细胞有丝分裂阻滞和细胞凋亡 (apoptosis)。MT 63-78 通过抑制脂肪生成和 mTORC1 途径来阻止前列腺癌的生长。MT 63-78 具有抗肿瘤作用。

靶点

AMPK

25 μM (EC ₅₀ )

mTORC1

体外研究

MT 63-78 (0-50 μM; 4 days; LNCaP and PC3 cells) treatment shows a dose-dependent decrease in cell number, and concomitant to the activation of AMPK signaling.
MT 63-78 (25 μM; 24 hours; LNCaP and CRPC cells) treatment induces a significant enrichement in the G2/M population.
MT 63-78 (0-50 μM; 24 hours; LNCaP, PC3, C4-4, C4-2B, CL1and 22RV1cells) treatment induces reduction of anti-apoptotic Mcl-1 in concert with accumulation of the pro-apoptotic BH3-only protein Puma.
MT 63-78 (0-50 μM; 30 minutes; LNCaP and PC3 cells) treatment shows a dose-dependent phosphorylation of the two major AMPK targets Acetyl-CoA Carboxylase (ACC) on Ser79 and of Raptor on Ser792. And also increases Thr172 phosphorylation on the AMPK α subunit.

Cell Viability Assay

Cell Line:	LNCaP and PC3 cells
Concentration:	0 μM, 1 μM, 5 μM, 10 μM, 25 μM, 50 μM
Incubation Time:	4 days
Result:	A dose-dependent decrease in cell number, concomitant to the activation of AMPK signaling was observed.

Cell Cycle Analysis

Cell Line:	LNCaP and CRPC cells
Concentration:	25 μM
Incubation Time:	24 hours
Result:	Induced a significant enrichement in the G2/M population in both androgen sensitive and CRPC cell models.

Apoptosis Analysis

Cell Line:	LNCaP, PC3, C4-4, C4-2B, CL1and 22RV1cells
Concentration:	0 μM, 10 μM, 25 μM, 50 μM
Incubation Time:	24 hours
Result:	Induced reduction of anti-apoptotic Mcl-1 in concert with accumulation of the pro-apoptotic BH3-only protein Puma in all PCa cells.

Western Blot Analysis

Cell Line:	LNCaP and PC3 cells
Concentration:	0 μM, 0.25 μM, 0.5 μM, 1 μM, 5 μM, 25 μM, 50 μM
Incubation Time:	30 minutes
Result:	Observed a dose-dependent phosphorylation of the two major AMPK targets Acetyl-CoA Carboxylase (ACC) on Ser79 and of Raptor on Ser792. A corresponding increase in Thr172 phosphorylation on the AMPK α subunit was also observed.

体内研究

MT 63-78 (30 mg/kg; intraperitoneal injection; daily; for 14 days; C57 BL/6 male mice) treatment leads to a 33% inhibition of tumor growth.

Animal Model:	C57 BL/6 male mice bearing LNCaP tumors
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection; daily; for 14 days
Result:	Led to a 33% inhibition of tumor growth.