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1210416-93-5

英文名称 LGB-321 HCl
CAS 1210416-93-5
分子式 C23H23ClF3N5O2
分子量 493.92
MOL 文件 1210416-93-5.mol
1210416-93-5 结构式 1210416-93-5 结构式

基本信息

英文别名
LGB-321 dihydrochloride

应用领域

用途一
LGB-321 is a potent and selective ATP-competitive small molecule inhibitor of PIM kinases (Pan-PIM kinase inhibitor). LGB321 is unique relative to previously described PIM inhibitors, in that it is active in PIM2 dependent cell lines. , a kinase that has proven difficult to inhibit in the cellular context. Consistent with its activity on all three PIM kinases, LGB321 inhibits proliferation of a number of cell lines derived from diverse hematological malignancies, including MM, AML, CML and B-Cell NHL. In vivo, LGB-321 is orally available, demonstrates efficacy in tumor xenografts and is well-tolerated within the therapeutic exposure range in mice. (source: Clin Cancer Res. 2014 Apr 1;20(7):1834-45 )
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