1219927-22-6
1219927-22-6 结构式
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-113618A | 化合物RO2959 HYDROCHLORIDE RO2959 hydrochloride | 1219927-22-6 | 1 mg | 1333元 |
| 2025/05/22 | HY-113618A | 化合物RO2959 HYDROCHLORIDE RO2959 hydrochloride | 1219927-22-6 | 5mg | 3500元 |
| 2023/01/06 | S3426 | RO2959 hydrochloride | 1219927-22-6 | 25mg | 22104.8元 |
常见问题列表
|
CRAC channel 402 nM (IC 50 ) |
Orai1/Stim1 channels 25 nM (IC 50 ) |
IL-2
|
RO2959 inhibits Orai1 and Orai3 with IC
50
values of 25 nM and 530 nM, respectively. RO2959 blocks store operated calcium entry (SOCE) in activated CD4+T lymphocytes with an IC
50
value of 265 nM.
RO2959 is a potent SOCE inhibitor that blocks an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4
+
T cells triggered by either T cell receptor (TCR) stimulation or thapsigargin treatment. RO2959 completely inhibits cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction).