1222781-70-5

中文名称 (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐

英文名称 ML 133 Hydrochloride

CAS 1222781-70-5

分子式 C19H20ClNO

分子量 313.821

MOL 文件 1222781-70-5.mol

1222781-70-5 结构式

基本信息物理化学性质安全数据常见问题列表图谱信息 (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐价格(试剂级)

基本信息

中文别名

ML133盐酸盐
(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐
N-[(4-甲氧基苯基)甲基]-1-萘甲胺盐酸盐
N-(4-甲氧基苄基)-1-(萘-1-基)甲胺盐酸盐
ML133 HCL (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐

英文别名

ML133 HCl
ML 133 Hydrochloride
CID 781301 hydrochloride
VU0404943-1 hydrchloride
SID 85281105 hydrochloride
ML 133 Hydrochloride USP/EP/BP
(4-Methoxybenzyl)(1-naphthylMethyl)aMine Hydrochloride
N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride
N-[(4-METHOXYPHENYL)METHYL]-1-NAPHTHALENEMETHANAMINE HYDROCHLORIDE
(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride

所属类别

生物化工：Potassium Channel 抑制剂

物理化学性质

熔点193-195°C

储存条件2-8°C

溶解度二甲基亚砜：≥10mg/mL

形态粉末

颜色白色至棕褐色

InChI1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H

InChIKeyNGQIBUUFXDPHKT-UHFFFAOYSA-N

SMILESCl.COc1ccc(CNCc2cccc3ccccc23)cc1

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS05,GHS07,GHS09

警示词危险

危险性描述H302-H315-H318-H335-H400

防范说明P273-P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

危险品标志Xn,N

危险类别码22-37/38-41-50/53

安全说明26-39-60-61

危险品运输编号UN 3077 9 / PGIII

WGK Germany3

存储类别11 - Combustible Solids

危险性类别Acute Tox. 4 Oral
Aquatic Acute 1
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

常见问题列表

生物活性

ML133 HCl是一种选择性钾离子通道抑制剂，作用于K_ir2.1， IC50为1.8 μM (pH 7.4)和290 nM (pH 8.5)，对K_ir1.1没有作用效果，对K_ir4.1和K_ir7.1具有微弱的作用活性。

体外研究

The ratio of total concentration of extracellular ML133 versus intracellular ML133 is 1:0.13 at pH 6.5, 1:9.09 at pH 8.5. ML133 is clean against 3A4 and 2C9 (IC50 >30 μM), displays moderate inhibition of 1A2 (IC50 = 3.3 μM) but proves to be a potent inhibitor of 2D6 (IC50 = 0.13 μM) in CYP450 assay. ML133 is highly protein bound (>99%) in both human and rat and also displays high intrinsic clearance in both species. ML133 (10 μM) is not displaced by K⁺ influx from the wild-type K_ir2.1 in HEK 293 cells. M1 and/or M2 transmembrane domains contain the critical molecular determinant for ML133 inhibition of K_ir2.1, especially D172 and I176.

靶点

IC50: 1.8 μM (K _ir 2 at pH 7.4), 290 nM (K _ir 2 at pH 8.5).

图谱信息

(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐(1222781-70-5)核磁图(¹HNMR)

(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/12/22	HY-100230A	(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 ML133 hydrochloride	1222781-70-5	5mg	500元
2025/12/22	HY-100230A	(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 ML133 hydrochloride	1222781-70-5	10mM * 1mLin DMSO	550元
2025/12/22	HY-100230A	(4-甲氧基苄基)(1-萘基甲基)胺盐酸盐 ML133 hydrochloride	1222781-70-5	10mg	700元