129735-01-9

中文名称 RP-8-CPT-CAMPS

英文名称 8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

CAS 129735-01-9

分子式 C16H15ClN5O5PS2

分子量 487.88

MOL 文件 129735-01-9.mol

129735-01-9 结构式

基本信息物理化学性质安全数据常见问题列表

基本信息

英文别名

RP-8-CPT-CAMPS
RP-8-CPT-CAMPS SODIUM SALT
8-(4-CHLOROPHENYLTHIO)ADENOSINE-*3',5-CYCLIC MONOPH
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER
Adenosine, 8-[(4-chlorophenyl)thio]-, cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate]
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
8-(4-chlorophenylthio)adenosine-3’,5’-cyclicmonophosphorothioate,spisomer(sp-8-cpt-camps),sodi

物理化学性质

储存条件−20°C

形态solid

生物来源synthetic (organic)

安全数据

WGK Germany3

常见问题列表

生物活性

Rp-8-CPT-cAMPS，一种 cAMP 类似物，是 cAMP 诱导的依赖 cAMP 的 PKA I 和 PKA II 活化的有效和竞争性的拮抗剂。Rp-8-CPT-cAMPS 优先选择 RI 的位点 A 与 RII 的位点 B。

靶点

PKA

体外研究

Rp-8-CPT-cAMPS (100 μM; 15 min) blocks phosphorylation of VASP by 6-Bnz-cAMP and largely reduces VASP phosphorylation by forskolin and fenoterol.
Rp-8-CPT-cAMPS (100 μM; 30 min) reduces GTP-loading of Rap1 by both 8-pCPT-2'-O-Me-cAMP and 6-Bnz-cAMP.
Rp-8-CPT-cAMPS (100 μM; 30 min) largely diminishes the augmentation of bradykinin-induced IL-8 release by the PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2'-O-Me-cAMP.
Rp-8-CPT-cAMPS (10 μM) inhibits the endothelium-dependent and -independent relaxation which induced by Venom in pre-contracted rat mesenteric artery rings.