1303607-59-1

中文名称化合物 MI-888 FREE BASE

英文名称 Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(cis-3-hydroxy-3-methylcyclobutyl)-2-oxo-, (2'S,3R,4'S,5'R)-

CAS 1303607-59-1

分子式 C28H32Cl2FN3O3

分子量 548.48

MOL 文件 1303607-59-1.mol

1303607-59-1 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

化合物 MI-888 FREE BASE

英文别名

Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(cis-3-hydroxy-3-methylcyclobutyl)-2-oxo-, (2'S,3R,4'S,5'R)-

物理化学性质

沸点712.2±60.0 °C(Predicted)

密度1.38±0.1 g/cm3(Predicted)

酸度系数(pKa)12.03±0.70(Predicted)

应用领域

用途一

MI-888 is a potent MDM2 inhibitor (Ki = 0.44 nM) with a superior pharmacokinetic profile and enhanced in vivo efficacy. MI-888 is capable of achieving rapid, complete, and durable tumor regression in two types of xenograft models of human cancer with oral administration and represents the most potent and efficacious MDM2 inhibitor reported to date.