130466-38-5
中文名称
130466-38-5
英文名称
Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1)
CAS
130466-38-5
分子式
C20H26N4O4S.ClH
更新日期
2023/03/20 15:41:21
分子量
454.97
MOL 文件
130466-38-5.mol
130466-38-5 结构式
基本信息
中文别名
化合物 T13285 英文别名
MK-467 hydrochlorideL-659066 hydrochloride
Vatinoxan hydrochloride
Methanesulfonamide,N-[2-[(2R,12bS)-1,3,4,6,7,12b-hexahydro-2'-oxospiro[2H-benzofuro[2,3-a]quinolizine-2,4'-imidazolidin]-3'-yl]ethyl]-,hydrochloride (1:1)
130466-38-5价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/12/22 | HY-19057A | Vatinoxan hydrochloride | 130466-38-5 | 1 mg | 3350元 |
| 2025/12/22 | HY-19057A | 130466-38-5 Vatinoxan hydrochloride | 130466-38-5 | 10 mM * 1 mLin DMSO | 8508元 |
| 2025/02/08 | HY-19057A | 130466-38-5 Vatinoxan hydrochloride | 130466-38-5 | 10 mM * 1 mLin Water | 8508元 |
常见问题列表
生物活性
Vatinoxan hydrochloride (MK-467hydrochloride;L-659066 hydrochloride) 是一种外周 α2 肾上腺素能受体 (α2 adrenergic receptor) 拮抗剂。靶点
α2 adrenergic receptor
体内研究
Vatinoxan alone increases cardiac index and tissue oxygen delivery and has no deleterious adverse effects. Vatinoxan attenuates or prevents dexmedetomidine’s systemic hemodynamic effects in a dose-dependent manner when given simultaneously i.v. but has no effect on the pulmonary outcome in conscious dogs. A 50:1 dose ratio (Vatinoxan:dexmedetomidine) induces the least alterations in cardiovascular function. Vatinoxan dose-dependently attenuates the bradycardia associated with dexmedetomidine, and shortens the sedative effect without altering its quality. Vatinoxan may be useful in attenuating reductions in heart rate in conscious catsadministered dexmedetomidine.