132-60-5
132-60-5 结构式
基本信息
阿托方
喹苯甲酸
苯基金鸡宁酸
2-苯辛可宁酸
2-苯辛可寧酸
2-苯-4-喹啉甲酸
2-苯基-4-喹啉羧酸
2-苯基喹啉-4-羧酸
2-苯基-4-喹啉甲酸
agotan
alutyl
atigoa
atocin
atofan
tophol
vantyl
RHEUMIN
artamin
物理化学性质
安全数据
常见问题列表
辛可芬的合成路线很多，将苯甲醛、苯胺和丙酮酸各一分子在乙醇溶液中加热，可一锅法制备得到。或以取代吲哚醌和取代苯乙酮为原料,无水乙醇为溶剂,在氢氧化钾的存在下加热反应生成取代2-苯基-4-喹啉羧酸。2-苯基-4-喹啉羧酸的合成反应式如下图：
Cinchophen（2 - 苯基喹啉-4 - 羧酸）是一个功能强大的抗菌剂。 兽医将Cinchophen和泼尼松龙组合使用，治疗动物的关节炎。由于发现cinchophen会引起严重的肝损伤， 1930s停止了该药在人体的使用。
Cinchophen (oral gavage; 25-44 mg/kg; twice daily) combines prednisolone ( 0.125-0.220 mg/kg; twice daily) for 14 days is effective in dogs with osteoarthritis and well tolerated. The combination exhibits significantly improved lameness, weight bearing, joint mobility and stiffness scores and is similar in clinical efficacy to phenylbutazone.The kinetics and efficacy of a cinchophen prednisolone combination preparation (PLT) is tested. Cinchophen administation at a dose rate of 12.5 mg/kg intravenously exhibits a volume of distribution (V d area) of 0.13 L/kg, shows a clearance rate (Cl) of 0.15 L/h and a half-life (t 1/2β ) of 7.92 hours. The plasma concentration time curve (AUC0-∞) is 1187.0 μ/ml.h in dogs. Cinchophen administation (oral gavage; 12.5 mg/kg; single dose) exhibits a mean maximum plasma concentration (C max ) of 77.75 μg/ml and the time of Cmax (t max ) is 2.76 hours. The plasma concentration time curve (AUC 0-∞ ) is almost as large following oral as intravenous administration indicating an oral bioavailability (F) of 87.21%.