134029-62-2
中文名称
3,4,5,4'-四甲氧基二苯乙烯
英文名称
3,4,5,4'-TETRAMETHOXYSTILBENE
CAS
134029-62-2
分子式
C18H20O4
分子量
300.35
MOL 文件
134029-62-2.mol
更新日期
2025/11/10 14:11:59
134029-62-2 结构式
基本信息
中文别名
3,4,5,4'-四甲氧基二苯乙烯 英文别名
DMU 212DMU-212
DMU 212
DMU212
3,4,5,4'-TETRAMETHOXYSTILBENE
(E)-3,4,5,4′-Tetramethoxystilbene
(E)-3,4,5,4'-Tetramethoxystilbene >=98% (HPLC)
(E)-1,2,3-Trimethoxy-5-[2-(4-methoxyphenyl)ethenyl]benzene
1,2,3-Trimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene
Benzene, 1,2,3-trimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-
3,4,5,4'-四甲氧基二苯乙烯价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-137977 | 3,4,5,4'-四甲氧基二苯乙烯 DMU-212 | 134029-62-2 | 1 mg | 248元 |
| 2025/05/22 | HY-137977 | 3,4,5,4'-四甲氧基二苯乙烯 DMU-212 | 134029-62-2 | 10mM * 1mLin DMSO | 550元 |
| 2025/05/22 | HY-137977 | 3,4,5,4'-四甲氧基二苯乙烯 DMU-212 | 134029-62-2 | 5 mg | 620元 |
常见问题列表
生物活性
DMU-212 是一种白藜芦醇 (HY-16561) 甲基化衍生物，具有抗分裂、抗增殖、抗氧化和促进细胞凋亡的活性。DMU-212 通过诱导凋亡 (apoptosis) 和激活 ERK1/2 蛋白导致有丝分裂停止。DMU-212 具有口服活性。体外研究
DMU-212 (0.3125-40 μM) inhibits growth of A375, MeWo, Bro and M5 cells human melanoma cells.
DMU-212 (30-50 μM; 24 hours) induces upregulation of cell cycle inhibitors, apoptosis and ERK activation in A375 cells.
DMU-212 induces upregulation of cell cycle inhibitors, apoptosis and ERK activation in A375 cells.
DMU-212 induces G2/M arrest and apoptosis in cancer cells.
DMU-212 induces mitotic arrest, apoptosis and activation of ERK1/2 protein.
Cell Proliferation Assay
| Cell Line: | A375 cells, MeWo cells, M5 cells, Bro cells |
| Concentration: | 0.3125 μM, 0,625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM |
| Incubation Time: | 96 hours |
| Result: | Inhibited the cellular proliferation of human melanoma cells at submicromolar or micromolar concentrations (IC 50 =0.5 μM for A375 and Bro and IC 50 = 1.25 μM for MeWo and M5 cells). |
Cell Cycle Analysis
| Cell Line: | A375 cells |
| Concentration: | 20 μM, 30 μM, 50 μM |
| Incubation Time: | 24 hours |
| Result: | Caused a marked increase in the levels of p21, p53 and cyclin B1 proteins with a concomitant decrease in the levels of cyclin A2. |
Western Blot Analysis
| Cell Line: | A375 cells |
| Concentration: | 20 μM, 30 μM, 50 μM |
| Incubation Time: | 24 hours |
| Result: | Significant upregulation of Bax, caspase 3 and caspase 9 protein levels, while the levels of the anti-apoptotic protein Bcl-2 were decreased. |
体内研究
DMU-212 (50 mg/kg; i.g.; three times a week; for 14 days) inhibits tumor growth in xenograft model of human ovarian cancer.
| Animal Model: | 6-weeks-old SCID female mice (20-24 g), with ovarian cancer xenografts |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage, three times a week, for 14 days |
| Result: | Lower tumor burden. |