1361504-77-9
1361504-77-9 结构式
基本信息
(Z)-2-(2-溴苯基)-3-(4-(4-甲基哌嗪-1-基)苯基)丙烯腈二盐酸盐
DG172 2HCl
DG-172 (hydrochloride)
DG172 (dihydrochloride)
(αZ)-2-Bromo-α-[[4-(4-methyl-1-piperazinyl)phenyl]methylene]benzeneacetonitrile dihydrochloride
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/12/22 | HY-19737A | 1361504-77-9 DG172 dihydrochloride | 1361504-77-9 | 5mg | 700元 |
| 2025/12/22 | HY-19737A | 1361504-77-9 DG172 dihydrochloride | 1361504-77-9 | 10mM * 1mLin Water | 770元 |
| 2025/12/22 | HY-19737A | 1361504-77-9 DG172 dihydrochloride | 1361504-77-9 | 10mg | 1200元 |
常见问题列表
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PPARβ/δ 27 nM (IC 50 ) |
DG172 dihydrochloride is a selective PPARβ/δ antagonist, with an IC 50 of 27 nM. DG172 enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts (IC 50 , 9.5 nM). DG172 (1 µM) promotes the differentiation of dendritic cells (DCs) from GM-CSF-induced mouse bone marrow cells (BMCs) and reduces Ly6b + /Gr1 + granulocytic cells. DG172 has effects on the transcriptome of GM-CSF differentiated BMCs from WT and Ppard null mice, and acts at a specific stage of GM-CSF-induced differentiation. DG172 (0.1, 1.0 µM) dose-dependently promotes proliferation of TM4 cells. DG172 reduces expression of claudin-11 in TM4 cells.