1417576-00-1
中文名称
Azilsartan Impurity 16
英文名称
Azilsartan Impurity 16
CAS
1417576-00-1
分子式
C28H20N4O8
分子量
540.48
MOL 文件
1417576-00-1.mol
更新日期
2026/09/03 15:02:03
1417576-00-1 结构式
基本信息
中文别名
美阿沙坦钾美阿沙坦钾杂质B
阿齐沙坦杂质112
阿齐沙坦杂质 16
英文别名
Azilsartan Impurity 16Azilsartan Impurity 112
Azilsartan Medoxomil O-Desethyl
2-Oxo-3-[2'-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-biphenyl-4-yl methyl]-3H-benzoimidazole-4-carboxylic acid 5-methyl-2-oxo-{1,3}dioxol-4-ylmethyl ester
所属类别
分析化学：药典标准品和杂质标准品物理化学性质
熔点164-168 °C
密度1.54±0.1 g/cm3(Predicted)
溶解度DMSO (Slightly), Methanol (Slightly, Heated)
酸度系数(pKa)6.85±0.20(Predicted)
形态Solid
颜色White to Off-White
InChIKeyMZPRTKPTVHPGEW-UHFFFAOYSA-N
SMILESC1(=O)NC2=CC=CC(C(OCC3=C(C)OC(=O)O3)=O)=C2N1CC1=CC=C(C2=CC=CC=C2C2=NC(=O)ON2)C=C1
应用领域
用途一
Desethyl Azilsartan Medoxomil is an impurity from the synthesis of Azilsartan Medoxomil (A926910). Azilsartan medoxomil is a long-acting angiotensin II receptor blocker (ARB) that is used to lower hypertension. When Azilsartan medoxomil enters the gastrointestinal tract, it is rapidly converted to its active form, Azilsartan (A926900).