142439-95-0
中文名称
Sp-Cyclic AMPS (sodium salt)
英文名称
Sp-Cyclic AMPS (sodium salt)
CAS
142439-95-0
分子式
C10H13N5NaO5PS
分子量
369.27
MOL 文件
142439-95-0.mol
142439-95-0 结构式
Sp-Cyclic AMPS (sodium salt)价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2026/06/05 | HY-100530C | Sp-Cyclic AMPS (sodium salt) Sp-cAMPS sodium salt | 142439-95-0 | 1 mg | 2000元 |
| 2026/06/05 | HY-100530C | Sp-Cyclic AMPS (sodium salt) Sp-cAMPS sodium salt | 142439-95-0 | 5 mg | 5000元 |
| 2026/06/05 | HY-100530C | Sp-Cyclic AMPS (sodium salt) Sp-cAMPS sodium salt | 142439-95-0 | 10 mM * 1 mL in DMSO | 5500元 |
常见问题列表
生物活性
Sp-cAMPS sodium salt，一种 cAMP 类似物，是一种依赖 cAMP 的 PKA I 和 PKA II 的有效激活剂。Sp-cAMPS sodium salt 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂，Ki 为 47.6 µM。Sp-cAMPS sodium salt 以 EC50 为 40 μM 来结合 PDE10 GAF 域。靶点
|
PKA I
|
PKA II
|
PDE3A 47.6 μM (Ki) |
PDE10 GAF domain 50 μM (EC 50 ) |
体外研究
Treatment of hepatocytes with Sp-cAMPS, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon. The glucagon-stimulated increases in the level of Ca 2+ can be mimicked by Sp-cAMPS.
体内研究
In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 µg/µL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals.