14325-05-4
中文名称
原卟啉二氯化锡(IV)
英文名称
TIN PROTOPORPHYRIN IX DICHLORIDE
CAS
14325-05-4
分子式
C34H36Cl2N4O4Sn
分子量
754.29
MOL 文件
14325-05-4.mol
更新日期
2023/03/20 15:41:21
14325-05-4 结构式
基本信息
中文别名
锡原卟啉IX锡原卟啉IX二氯乙烷
原卟啉二氯化锡(IV)
锡(IV) 卟啉 IX 二氯
英文别名
SnPPIXNsc267099
TINPROTOPORPHYRIN
tin protoporphyrin IX
TIN PROTOPORPHYRIN IX DICHLORIDE
Tin Protoporphyrin IX (chloride)
Stannate(2-) dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid]
物理化学性质
储存条件Store at RT
溶解度Soluble to 25 mM in 1eq. NaOH and to 5 mM in DMSO
形态深红色至紫色固体。
颜色Brown to reddish brown
原卟啉二氯化锡(IV)价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-101194 | 原卟啉二氯化锡(IV) Tin-protoporphyrin IX | 14325-05-4 | 5mg | 2500元 |
| 2025/02/08 | HY-101194 | 原卟啉二氯化锡(IV) Tin-protoporphyrin IX | 14325-05-4 | 10mg | 3200元 |
| 2023/03/20 | HY-101194 | 原卟啉二氯化锡(IV) Tin-protoporphyrin IX | 14325-05-4 | 50mg | 9500元 |
常见问题列表
生物活性
Tin-protoporphyrin IX (SnPPIX) 是有效的血红素加氧酶-1 (HO-1) 抑制剂。 Tin-protoporphyrin IX (SnPPIX) 使 PDAC 管腺癌肿瘤对化疗敏感。靶点
IC50: Heme oxygenase-1 (HO-1)
体外研究
Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM.
Cell Viability Assay
| Cell Line: | Capan-1, CD18/HPAF, PDAC cells |
| Concentration: | 20 μM, 50 μM |
| Incubation Time: | 24 or 72 hours |
| Result: | Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM. |
体内研究
Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment.
| Animal Model: | Male and female athymic nude mice with PDAC cell-derived xenograft tumors |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20 |
| Result: | Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine). |