1443373-17-8
中文名称
1443373-17-8
英文名称
AM-2099
CAS
1443373-17-8
分子式
C19H13F3N4O3S2
分子量
466.46
MOL 文件
1443373-17-8.mol
更新日期
2024/12/03 15:40:34
1443373-17-8 结构式
基本信息
中文别名
化合物 T14201 英文别名
AM-2099AM 2099
AM-2099
4-[2-Methoxy-4-(trifluoromethyl)phenyl]-N-2-thiazolyl-7-quinazolinesulfonamide
7-Quinazolinesulfonamide, 4-[2-methoxy-4-(trifluoromethyl)phenyl]-N-2-thiazolyl-
物理化学性质
沸点572.1±60.0 °C(Predicted)
密度1.531±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : ≥ 150 mg/mL (321.57 mM)
酸度系数(pKa)6.11±0.50(Predicted)
形态Solid
颜色White to off-white
应用领域
用途一
AM-2099 is a potent and selective NaV1.7 Inhibitor (hNav1.7 IC50 = 0.16 uM; hNav1.5 IC50 > 30 uM; Papp = 31 x 10 (-6)cm/s; Rat IV CL (b/h/kg) \= 0.54; cLogD = 2.1). AM-2099 demonstrated a favorable pharmacokinetic profile in rat and dog and demonstrated dose-dependent reduction of histamine-induced scratching bouts in a mouse behavioral model following oral dosing.