1449686-84-3
中文名称
TIPEPIDINE HYDROCHLORIDE
英文名称
Piperidine, 3-(di-2-thienylmethylene)-1-methyl-, hydrochloride (1:1)
CAS
1449686-84-3
分子式
C15H17NS2.ClH
分子量
311.89
MOL 文件
1449686-84-3.mol
1449686-84-3 结构式
基本信息
中文别名
化合物TIPEPIDINE HYDROCHLORIDE 英文别名
Tipepidine hydrochloridePiperidine, 3-(di-2-thienylmethylene)-1-methyl-, hydrochloride (1:1)
TIPEPIDINE HYDROCHLORIDE价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-121685A | TIPEPIDINE HYDROCHLORIDE Tipepidine hydrochloride | 1449686-84-3 | 10mM * 1mLin DMSO | 446元 |
| 2025/05/22 | HY-121685A | TIPEPIDINE HYDROCHLORIDE Tipepidine hydrochloride | 1449686-84-3 | 5mg | 650元 |
| 2025/05/22 | HY-121685A | TIPEPIDINE HYDROCHLORIDE Tipepidine hydrochloride | 1449686-84-3 | 10mg | 950元 |
常见问题列表
生物活性
Tipepidine hydrochloride 可逆地抑制多巴胺 D2 受体介导的 GIRK 电流 (IDA(GIRK))，从而激活 VTA 多巴胺神经元， 对 IDA(GIRK) 的 IC50 为 7.0 μM。Tipepidine hydrochloride 是一种非麻醉性镇咳药，具有抗抑郁样作用。靶点
IC50: 7.0 μM (dopamine D 2 receptor)
体内研究
Tipepidine (i.p.; 10-40 mg/kg; 0.5-23 hours) significantly decreases the immobility time in the forced swimming test in ACTH-treated rats. Tipepidine (i.p.; 40 mg/kg) increases the extracellular dopamine level of the nucleus accumbens (NAc) in ACTH-treated rats.
| Animal Model: | Male Wistar rats weighting 150-240 g (5-7 weeks old) |
| Dosage: | 10, 20 and 40 mg/kg |
| Administration: | I.p.; 0.5, 5, 23 hours |
| Result: | Decreased the immobility time in the forced swimming test in ACTH-treated rats. |