1453833-30-1
中文名称
化合物 T27805
英文名称
LDC-3140 (LDC043140)
CAS
1453833-30-1
分子式
C23H33N7O
分子量
423.55
MOL 文件
1453833-30-1.mol
1453833-30-1 结构式
应用领域
用途一
LDC3140, also known as LDC043140, is a potent CDK7 inhibitor. Cyclin-dependent kinase 7 (CDK7) activates cell cycle CDKs and is a member of the general transcription factor TFIIH. Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells.