151358-47-3
151358-47-3 结构式
基本信息
4(二(1H-吲哚-3-基)甲基)苯酚
DIM-C-pPhOH
DIM-C-pPhOH(CDIM8)
4-(di(1H-indol-3-yl)Methyl)phenol
4-[bis(1H-indol-3-yl)methyl]phenol
Phenol, 4-(di-1H-indol-3-ylmethyl)-
1,1-Bis(3'-indolyl)-1-(p-hydroxyphenyl)methane
物理化学性质
制备方法
120-72-9
123-08-0
151358-47-3
通用方法：将BiVO4纳米颗粒（BiVO4-NPs，30 mg）加入至含有吲哚或2-甲基吲哚（2 mmol）与醛类化合物（1 mmol）的混合物中。在无溶剂条件下，将反应混合物于80℃搅拌反应适当时间。反应进程通过薄层色谱（TLC）监测。反应完成后，用30 mL热乙醇稀释反应混合物，通过过滤回收催化剂，并用乙醇（5 mL）洗涤。减压蒸发溶剂，剩余固体通过乙醇/水（95:5，v/v）混合溶剂重结晶，得到纯产物4-(二(1H-吲哚-3-基)甲基)苯酚。所有产物的光谱及物理数据与文献报道一致，并与按先前报道方法制备的样品相符。
参考文献：
[1] Tetrahedron Letters, 2003, vol. 44, # 9, p. 1959 - 1961
[2] Journal of Chemical Research, 2004, # 1, p. 34 - 36
[3] Monatshefte fur Chemie, 2004, vol. 135, # 10, p. 1265 - 1273
[4] RSC Advances, 2016, vol. 6, # 96, p. 93546 - 93550
[5] Synthetic Communications, 2004, vol. 34, # 3, p. 487 - 492
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-112055 | 4(二(1H-吲哚-3-基)甲基)苯酚 DIM-C-pPhOH | 151358-47-3 | 1mg | 500元 |
| 2025/05/22 | HY-112055 | 4(二(1H-吲哚-3-基)甲基)苯酚 DIM-C-pPhOH | 151358-47-3 | 5mg | 750元 |
| 2025/05/22 | HY-112055 | 4(二(1H-吲哚-3-基)甲基)苯酚 DIM-C-pPhOH | 151358-47-3 | 10mM * 1mLin DMSO | 825元 |
常见问题列表
| Target | Value |
|
Nur77
(786-O cells based assay) | 13.0 μM |
|
Nur77
(ACHN cells based assay) | 13.6 μM |
DIM-C-pPhOH (7.5-20 μM; 24 hours; ACHN and 786-O cells) treatment significantly decreases cell proliferation.
DIM-C-pPhOH (20 μM; 24 hours; ACHN and 786-O cells) treatment induces Annexin V staining in ACHN and 786-O cells, confirming that DIM-C-pPhOH induce apoptosis, and also induces cleavage of caspases 7 and 8.
DIM-C-pPhOH (15-20 μM; 24 hours; ACHN and 786-O cells) treatment inhibits NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induces sestrin 2, activates AMPKα and inhibits activation of mTOR and downstream kinases.
DIM-C-pPhOH decreases expression of β1-integrin protein and mRNA and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells and also inhibits migration of the latter two cell lines.
Cell Proliferation Assay
| Cell Line: | ACHN and 786-O cells |
| Concentration: | 7.5 μM, 15 μM, 20 μM |
| Incubation Time: | 24 hours |
| Result: | Significantly decreased cell proliferation. |
Apoptosis Analysis
| Cell Line: | ACHN and 786-O cells |
| Concentration: | 20 μM |
| Incubation Time: | 24 hours |
| Result: | Induced apoptosis in ACHN and 786-O cells. |
Western Blot Analysis
| Cell Line: | ACHN and 786-O cells |
| Concentration: | 15 μM, 20 μM |
| Incubation Time: | 24 hours |
| Result: | Inhibited NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induced sestrin 2, activated AMPKα and inhibited activation of mTOR and downstream kinases. |
DIM-C-pPhOH (30 mg/kg; oral gavage; daily; for 50 days; male athymic nude mice) treatment results in a significant inhibition of tumor growth.
| Animal Model: | Male athymic nude mice (aged 6-7 weeks) injected with ACHN cells |
| Dosage: | 30 mg/kg/day |
| Administration: | Oral gavage; daily; for 50 days |
| Result: | Resulted in a significant inhibition of tumor growth. |