151533-34-5
中文名称
ACOLBIFENE
英文名称
ACOLBIFENE
CAS
151533-34-5
分子式
C29H31NO4
分子量
457.56
MOL 文件
151533-34-5.mol
更新日期
2023/03/20 15:41:33
151533-34-5 结构式
基本信息
中文别名
化合物 T12654 英文别名
ACOLBIFENE(Rac)-EM-652
rac-Acolbifene
2H-1-Benzopyran-7-ol, 3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-
2-[4-[2-(1-piperidino)ethoxy]phenyl]-3-(4-hydroxyphenyl)-4-Methyl-7-hydroxy-2H-1-benzopyran
物理化学性质
沸点651.5±55.0 °C(Predicted)
密度1.217±0.06 g/cm3(Predicted)
溶解度DMSO: 100 mg/mL (218.55 mM)
酸度系数(pKa)9.70±0.40(Predicted)
形态Crystal
颜色Purple to purplish red
ACOLBIFENE价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-16023B | ACOLBIFENE (Rac)-Acolbifene | 151533-34-5 | 5mg | 1500元 |
| 2025/05/22 | HY-16023B | ACOLBIFENE (Rac)-Acolbifene | 151533-34-5 | 10mM * 1mLin DMSO | 1510元 |
| 2025/05/22 | HY-16023B | ACOLBIFENE (Rac)-Acolbifene | 151533-34-5 | 10mg | 2500元 |
常见问题列表
生物活性
(Rac)-Acolbifene (EM-343; (Rac)-EM-652) 是 EM652 (estrogen receptor 拮抗剂) 的外消旋形式，具有抗雌激素和雌激素活性。 (Rac)-Acolbifene (EM-343; (Rac)-EM-652) 含哌啶环，具有良好的药理作用，RBA=380。体外研究
(Rac)-Acolbifene (EM-343; (Rac)-EM-652) shows a inhibitory effect in T-47D cells with an IC 50 value of 0.110 nM.
Cell Viability Assay
| Cell Line: | T-47D cells |
| Concentration: | 0.110 nM |
| Incubation Time: | 72 hours |
| Result: | Inhibited T-47D cells growth. |
体内研究
(Rac)-Acolbifene (orally adminstration; 7.5 nM, 75 nM; 9 days; once daily) shows a good pharmacological profile in ovariectomized mice, shows 63% and 84% antiuterotrophic inhibitions at the 7.5 and 75 nM doses, respectively (PK study, ovariectomized mice).